期刊
NEUROREPORT
卷 20, 期 16, 页码 1414-1418出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e328330b735
关键词
IGF2; Igf2(-/-) mice; motor neurons; neuronal survival; sciatic nerve transection
资金
- Harvard Scholars in Medicine Award
- NIH [R01 GM071046]
The search for therapeutic targets to prevent neurons from dying is ongoing and involves the exploration of a long list of neurotrophic factors. Insulin-like growth factor 2 (IGF2) is a member of the insulin family with known neurotrophic properties. In this study, we used Igf2 knockout (Igf2(-/-)) neonate mice to determine whether lgf2 deficiency is detrimental to motor neuron survival after axonal injury. Results show that Igf2(-/-) neonatal mice are more susceptible to motor neuron damage than Igf2(+/+) mice, as they have a significantly lower percentage of motor neuron survival after a sciatic nerve transection. Neuronal survival was significantly improved in Igf2(-/-) mice when IGF2 was administered. These results support the role of IGF2 in neonatal motor neuron survival. NeuroReport 20:1414-1418 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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