期刊
NEUROREPORT
卷 19, 期 8, 页码 873-876出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e3282ffda5e
关键词
alpha-synuclein; colonic motility; corticotropin releasing factor; mouse; Parkinson's disease; stress
资金
- NIDDK NIH HHS [R01 DK057238, R01 DK 57238] Funding Source: Medline
- NINDS NIH HHS [P50 NS038367, P50 NS038367-07, P50NS38367] Funding Source: Medline
- PHS HHS [41301] Funding Source: Medline
The presynaptic protein alpha-synuclein (alpha Syn) has been implicated in both familial and sporadic forms of Parkinson's disease. We examined whether human alpha Syn-overexpressing mice under Thy1 promoter (Thy1-alpha Syn) display alterations of colonic function. Basal fecal output was decreased in Thy1-alpha Syn mice fed ad libitum. Fasted/refed Thy1-alpha Syn mice had a slower distal colonic transit than the wild-type mice, as monitored by 2.2-fold increase in time to expel an intracolonic bead and 2.9-fold higher colonic fecal content. By contrast, Thy1-alpha Syn mice had an increased fecal response to novelty stress and corticotropin releasing factor injected intraperipherally. These results indicate that Thy1-alpha Syn mice display altered basal and stress-stimulated propulsive colonic motility and will be a useful model to study gut dysfunction associated with Parkinson's disease.
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