期刊
NEUROREPORT
卷 19, 期 17, 页码 1699-1703出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0b013e32831743fb
关键词
astrocytes; erythropoietin; hypoxia-inducible factor-1; insulin-like growth factor-1
资金
- Korea Research Foundation [KRF-2003-015-E00086]
- Korea Science and Engineering Foundation (KOSEF)
- Korean government (MOST) [R11-2007-040-01006-0]
- National Research Foundation of Korea [2003-015-E00086, R11-2007-040-01006-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interestingly, blocking the potential action of secreted EPO on LN215 cells with EPO antibody, EPO receptor antibody, and soluble EPO receptor significantly suppressed the effect of IGF-1 on the biosynthesis of EPO. Synergistic action between IGF-1 and recombinant human EPO in the astrocytic production of EPO was observed. These data suggest that the IGF-1-EPO production/secretion process initiates a positive feedback loop of EPO biosynthesis in astrocytes, providing a molecular link between the two neuroprotective cytokines. NeuroReport 19:1699-1703 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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