期刊
NEUROPSYCHOPHARMACOLOGY
卷 37, 期 7, 页码 1764-1772出版社
SPRINGERNATURE
DOI: 10.1038/npp.2012.23
关键词
deep brain stimulation; depression; EEG; theta cordance; biomarker
资金
- Dana Foundation
- Stanley Medical Research Institute
- Woodruff Foundation
- Emory Healthcare
- Greenwall Foundation
- National Institutes of Health
- National Institute of Mental Health (NIMH)
- Northstar
- AvaCat Consulting
- St Jude Medical
- Oppenheimer
- NARSAD
- [K23 MH077869]
Deep brain stimulation (DBS) of subcallosal cingulate white matter (SCC) may be an effective approach for treatment-resistant depression (TRD) that otherwise fails to respond to more conventional therapies, but DBS is invasive, costly, and has potential for adverse effects. Therefore, it is important to identify potential biomarkers for predicting antidepressant response before intervention. Resting-state EEG was recorded from 12 TRD patients at pre-treatment baseline, after 4 weeks SCC DBS, and after 24 weeks SCC DBS. Lower frontal theta cordance (FTC) at baseline (and higher FTC after 4 weeks) predicted lower depression severity scores after 24 weeks. Greater FTC increases (baseline-4 weeks) predicted greater decreases in depression severity scores subsequently (4-24 weeks) and over the course of the study (baseline-24 weeks). Predictive relationships were topographically specific to theta cordance for frontal electrodes. Thus, results from this pilot study suggest that baseline FTC and changes early in treatment each have utility as biomarkers for predicting 6-month clinical response to SCC DBS for TRD. Neuropsychopharmacology (2012) 37, 1764-1772; doi:10.1038/npp.2012.23; published online 14 March 2012
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