期刊
NEUROPSYCHOPHARMACOLOGY
卷 36, 期 12, 页码 2452-2459出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2011.132
关键词
depression; inflammation; TNF; IL-6; IL-1; antidepressant
资金
- National Institute of Drug Addiction [K12DA00167]
- National Institute of Mental Health (Yale Child Study Center) [1K23MH091240-01]
- APIRE/Eli Lilly
- AACAP/Eli Lilly
- NARSAD
- National Center for Research Resources, a component of the National Institutes of Health [UL1 RR024139]
- NIH
Serum levels of inflammatory cytokines, for example, tumor necrosis factor alpha (TNF alpha), interleukin-6 (IL-6), and IL-1 beta (1L-1 beta), are elevated in subjects with major depressive disorder (MDD). The reason why this occurs is unclear. Elevated levels of inflammatory cytokines could be a result of brain dysfunction in MDD. It is also possible that inflammatory cytokines contribute to depressive symptoms in MDD. If the first assumption is correct, one would expect levels to normalize with resolution of the depressive episode after treatment. Several studies have measured changes in cytokine levels during antidepressant treatment; however, the results vary. The purpose of this study was to pool all available data on changes in serum levels of TNF alpha, IL-6, and IL-1 beta during antidepressant treatment to determine whether these levels change. Studies were included if they used an approved pharmacological treatment for depression, patients had a diagnosis of MDD, and serum levels of TNF alpha, IL-6, and/or IL-1 beta were measured before and after treatment. Twenty-two studies fulfilled these criteria. Meta-analysis of these studies showed that, overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNF alpha. On the other hand, antidepressant treatment did reduce levels of IL-1 beta and possibly those of IL-6. Stratified subgroup analysis by class of antidepressant indicated that serotonin reuptake inhibitors may reduce levels of IL-6 and TNF alpha. Other antidepressants, while efficacious for depressive symptoms, did not appear to reduce cytokine levels. These results argue against the notion that resolution of a depressive episode is associated with normalization of levels of circulating inflammatory cytokines; however, the results are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects of inflammatory cytokines on the brain. Neuropsychopharmacology (2011) 36, 2452-2459; doi: 10.1038/npp.2011.132; published online 27 July 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据