期刊
NEUROPSYCHOPHARMACOLOGY
卷 36, 期 5, 页码 1114-1125出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2010.249
关键词
nicotine; gestation; attention; impulsivity; dopamine system; ADHD
资金
- Wellcome Trust [079314]
- Janssen-Cilag
- Eli-Lilly
- Shire
- Flynn Pharma
- Medical Research Council [G9817803B] Funding Source: researchfish
Cigarette smoking is associated with a wide variety of adverse reproductive outcomes, including increased infant mortality and decreased birth weight. Prenatal exposure to tobacco smoke, of which nicotine is a major teratogenic component, has also been linked to the acceleration of the risk for different psychiatric disorders, including conduct disorder and attention deficit hyperactivity disorder (ADHD). Whether this increased risk is influenced by the direct effects of gestational nicotine exposure on the developing fetus remains uncertain. In this study we provide experimental evidence for the effects of prenatal nicotine exposure on measures of attention and impulsivity in adult male rats. Offspring of females exposed during pregnancy to 0.06 mg/ml nicotine solution as the only source of water (daily consumption: 69.6+/-1.4 ml/kg; nicotine blood level: 96.0+/-31.9 ng/ml) had lower birth weight and delayed sensorimotor development measured by negative geotaxis, righting reflex, and grip strength. In the 5-choice serial reaction time test, adult rats showed increased numbers of anticipatory responses and omissions errors, more variable response times, and lower accuracy with evidence of delayed learning of the task demands when the 1 s stimulus duration was introduced. In contrast, prenatal nicotine exposure had no effect on exploratory locomotion or delay-discounting test. Prenatal nicotine exposure increased expression of the D5 dopamine receptor gene in the striatum, but did not change expression of other dopamine-related genes (DRD4, DAT1, NR4A2, and TH) in either the striatum or the prefrontal cortex. These data suggest a direct effect of prenatal nicotine exposure on important aspects of attention, inhibitory control, or learning later in life. Neuropsychopharmacology (2011) 36, 1114-1125; doi:10.1038/npp.2010.249; published online 2 February 2011
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