期刊
NEUROPSYCHOPHARMACOLOGY
卷 37, 期 1, 页码 247-260出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2011.85
关键词
learning and memory; neurodegeneration; neuroprotection; drug discovery; development; epigenetics
资金
- NINDS
- NIMH
- NIA
- NIDA
- Rett Syndrome Foundation
- Ellison Medical Foundation
- Evelyn F McKnight Brain Research Foundation
Epigenetic mechanisms integrate signals from diverse intracellular transduction cascades and in turn regulate genetic readout. Accumulating evidence has revealed that these mechanisms are critical components of ongoing physiology and function in the adult nervous system, and are essential for many cognitive processes, including learning and memory. Moreover, a number of psychiatric disorders and syndromes that involve cognitive impairments are associated with altered epigenetic function. In this review, we will examine how epigenetic mechanisms contribute to cognition, consider how changes in these mechanisms may lead to cognitive impairments in a range of disorders and discuss the potential utility of therapeutic treatments that target epigenetic machinery. Finally, we will comment on a number of caveats associated with interpreting epigenetic changes and using epigenetic treatments, and suggest future directions for research in this area that will expand our understanding of the epigenetic changes underlying cognitive disorders. Neuropsychopharmacology Reviews (2012) 37, 247-260; doi: 10.1038/npp.2011.85; published online 18 May 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据