期刊
NEUROPSYCHOPHARMACOLOGY
卷 36, 期 1, 页码 74-97出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2010.151
关键词
dopamine; norepinephrine; opponency; psychiatry and behavioral sciences; reinforcement learning; serotonin
资金
- Gatsby Charitable Foundation
Affective valence lies on a spectrum ranging from punishment to reward. The coding of such spectra in the brain almost always involves opponency between pairs of systems or structures. There is ample evidence for the role of dopamine in the appetitive half of this spectrum, but little agreement about the existence, nature, or role of putative aversive opponents such as serotonin. In this review, we consider the structure of opponency in terms of previous biases about the nature of the decision problems that animals face, the conflicts that may thus arise between Pavlovian and instrumental responses, and an additional spectrum joining invigoration to inhibition. We use this analysis to shed light on aspects of the role of serotonin and its interactions with dopamine. Neuropsychopharmacology Reviews (2011) 36, 74-97; doi: 10.1038/npp.2010.151; published online 29 September 2010
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