期刊
NEUROPSYCHOPHARMACOLOGY
卷 34, 期 4, 页码 932-943出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/npp.2008.81
关键词
default-mode network; negative BOLD responses; major depressive disorder; event-related fMRI; emotional processing
资金
- German Research Foundation [DFG, 304/4-1]
- Swiss National Research Foundation [3100A0-100830]
- Research Foundation at the University of Zurich, Organon, Switzerland
- Salus Foundation Sachsen Anhalt/Germany
- ETH Zurich (SEP)
- Philips Medical Systems
- Hartmann-Muller-Foundation
- Gebert-Ruf-Foundation
- German Federal Ministry of Education and Research [BMBF-01GWSO61]
- Hope of Depression Research Foundation
Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional-cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.
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