期刊
NEUROPSYCHOLOGY REVIEW
卷 24, 期 3, 页码 300-312出版社
SPRINGER
DOI: 10.1007/s11065-014-9267-4
关键词
Aging; Preclinical Alzheimer's disease; Beta-amyloid; Amyloid PET imaging; Resilience
资金
- NIH [F32-AG044054, P01-AG036694]
Aberrant accumulation of beta-amyloid (A beta) is thought to be an early event in a biological cascade that eventually leads to Alzheimer's disease (AD). Along these lines, many clinically normal (CN) older individuals have evidence of beta-amyloid (A beta) accumulation, which may be indicative of preclinical AD. However, relationships between A beta and downstream AD markers are often inconsistent across studies. These inconsistencies may be due to the presence of other age-related processes that also influence AD markers, as well as additional risk factors that interact with A beta to influence downstream changes. For instance, it is possible that the effect of A beta is modified by neurodegeneration, genetics, sex-differences and cognitive reserve. Thus, a multivariate approach to determining risk of AD within CN participants may be more appropriate than reliance on A beta status alone. An understanding of how additional risk factors interact with A beta to influence an individual's trajectory towards AD is essential for characterizing preclinical AD and has implications for prevention trials.
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