期刊
NEUROPSYCHOLOGY REVIEW
卷 24, 期 1, 页码 16-31出版社
SPRINGER
DOI: 10.1007/s11065-014-9250-0
关键词
Autism; fMRI; Functional connectivity; Underconnectivity; Effective connectivity; White matter integrity
资金
- McNulty-Civitan Scientist award
- UAB department of Psychology faculty funds
- UAB Center for Clinical and Translational Sciences grant [UL1 TR000165]
Autism is a neurodevelopmental disorder that has been associated with atypical brain functioning. Functional connectivity MRI (fcMRI) studies examining neural networks in autism have seen an exponential rise over the last decade. Such investigations have led to the characterization of autism as a distributed neural systems disorder. Studies have found widespread cortical underconnectivity, local overconnectivity, and mixed results suggesting disrupted brain connectivity as a potential neural signature of autism. In this review, we summarize the findings of previous fcMRI studies in autism with a detailed examination of their methodology, in order to better understand its potential and to delineate the pitfalls. We also address how a multimodal neuroimaging approach (incorporating different measures of brain connectivity) may help characterize the complex neurobiology of autism at a global level. Finally, we also address the potential of neuroimaging-based markers in assisting neuropsychological assessment of autism. The quest for a neural marker for autism is still ongoing, yet new findings suggest that aberrant brain connectivity may be a promising candidate.
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