期刊
NEUROPSYCHOLOGY REVIEW
卷 20, 期 3, 页码 261-270出版社
SPRINGER
DOI: 10.1007/s11065-010-9143-9
关键词
Cerebellum; Basal ganglia; Virus tracing; Parkinson's disease; Dystonia
资金
- Office of Research and Development, Medical Research Service, Department of Veterans Affairs, National Institute of Health [R01 NS24328, R01 MH56661, P40 RR018604]
- Natural Sciences and Engineering Research Council of Canada [358419]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P40RR018604] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH056661] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS024328] Funding Source: NIH RePORTER
The cerebellum and the basal ganglia are major subcortical nuclei that control multiple aspects of behavior largely through their interactions with the cerebral cortex. Discrete multisynaptic loops connect both the cerebellum and the basal ganglia with multiple areas of the cerebral cortex. Interactions between these loops have traditionally been thought to occur mainly at the level of the cerebral cortex. Here, we review a series of recent anatomical studies in nonhuman primates that challenge this perspective. We show that the anatomical substrate exists for substantial interactions between the cerebellum and the basal ganglia. Furthermore, we discuss how these pathways may provide a useful framework for understanding cerebellar contributions to the manifestation of two prototypical basal ganglia disorders, Parkinson's disease and dystonia.
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