期刊
NEUROPSYCHOLOGY REVIEW
卷 20, 期 3, 页码 280-289出版社
SPRINGER
DOI: 10.1007/s11065-010-9141-y
关键词
Cerebellum; Alcohol; Alcoholism; Executive function; Structural imaging; Functional imaging
资金
- U.S. National Institute on Alcohol Abuse and Alcoholism [AA010723, AA017168, AA017923]
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [U01AA017923, R01AA010723, K05AA017168, R37AA010723] Funding Source: NIH RePORTER
Neuropathological, neuropsychological, and neuroimaging studies of human alcoholism provide evidence for degradation of frontal, pontine, thalamic, and cerebellar brain sites and disturbed associated functions. Current studies using neuroimaging combined with examination of executive functions, traditionally considered the sole purview of the frontal lobes, have identified a role for the cerebellum serving as a compensatory processing adjunct to enable normal performance on challenging tasks tapping executive functions. This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on the other hand, lead to compensation for dysfunctions in alcoholism traditionally considered frontally-based.
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