期刊
NEUROPSYCHOLOGY REVIEW
卷 19, 期 3, 页码 294-311出版社
CONSULTANTS BUREAU/SPRINGER
DOI: 10.1007/s11065-009-9098-x
关键词
Schizophrenia; Neuropsychology; Cognitive neuroscience; Preserved function
资金
- NCRR NIH HHS [M01 RR016500] Funding Source: Medline
- NIMH NIH HHS [P30 MH068580, R24 MH072647, MH72647, MH080066, R01 MH080066, MH065034, R01 MH065034] Funding Source: Medline
Patients with schizophrenia demonstrate marked impairments on most clinical neuropsychological tests. These findings suggest that patients suffer from a generalized form of cognitive impairment, with little evidence of spared performance documented in several large meta-analytic reviews of the clinical literature. In contrast, we review evidence for relative sparing of aspects of attention, procedural memory, and emotional processing observed in studies that have employed experimental approaches adapted from the cognitive and affective neuroscience literature. These islands of preserved performance suggest that the cognitive deficits in schizophrenia are not as general as they appear to be when assayed with clinical neuropsychological methods. The apparent contradiction in findings across methods may offer important clues about the nature of cognitive impairment in schizophrenia. The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness.
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