期刊
NEUROPSYCHOLOGY
卷 23, 期 1, 页码 105-116出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0013487
关键词
aging; vascular risk; memory; fluid intelligence; single nucleotide polymorphisms
资金
- National Institutes of Health [R37-AG-11230]
- NATIONAL INSTITUTE ON AGING [R03AG024630, R37AG011230, R01AG011230] Funding Source: NIH RePORTER
Several single nucleotide polymorphisms have been linked to neural and cognitive variation in healthy adults. We examined contribution of three polymorphisms frequently associated with individual differences in cognition (Catechol-O-Methyl-Transferase, Va1158Met, Brain-Derived-Neurotrophic-Factor Va166Met, and Apolipoprotein E epsilon 4) and a vascular risk factor (hypertension) in a sample of 199 volunteers (age 18-82). Genotypes were determined from buccal culture samples, and cognitive performance was assessed in 4 age-sensitive domains-fluid intelligence, executive function (inhibition), associative memory, and processing speed. We found that Younger age and COMT Met/Met genotype, associated with low COMT activity and higher prefrontal dopamine content, were independently linked to better performance in most of the tested domains. Homozygotes for Val allele of BDNF polymorphism exhibited better associative memory and faster speed of processing than the Met allele carriers, with greater effect for women and persons with hypertension, Carriers of ApoE epsilon 4 allele evidenced steeper age-related increase in costs of Stroop color interference, but showed no negative effects on memory. The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status.
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