期刊
NEUROPSYCHOLOGIA
卷 49, 期 3, 页码 479-485出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2010.12.015
关键词
fMRI; Striatum; vmPFC; Reward; Motivation; Temperament
资金
- National Institute of Mental Health [R01 MH 074454]
- National Institute of Child Health and Development [5R37 HD 017899-20]
- National Institutes of Health-National Institute of Mental Health
- National Science Foundation
The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value. (C) 2010 Elsevier Ltd. All rights reserved.
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