期刊
NEUROPSYCHOLOGIA
卷 48, 期 12, 页码 3665-3670出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2010.07.022
关键词
Autism; Asperger s disorder; Amygdala; Anxiety; Emotional face processing; Fusiform face area
资金
- NICHD [U19HD34565, P30HD002274]
- NIMH [U54MH066399]
Difficulty interpreting facial expressions has been reported in autism spectrum disorders (ASD) and is thought to be associated with amygdala abnormalities To further explore the neural basis of abnormal emotional face processing in ASD we conducted an fMRI study of emotional face matching in high-functioning adults with ASD and age IQ, and gender matched controls In addition we investigated whether there was a relationship between self-reported social anxiety and fMRI activation During fMRI scanning study participants were Instructed to match facial expressions depicting fear or anger The control condition was a comparable shape-matching task The control group evidenced significantly increased left prefrontal activation and decreased activation in the occipital lobes compared to the ASD group during emotional face matching Further within the ASD group greater social anxiety was associated with Increased activation in right amygdala and left middle temporal gyrus and decreased activation in the fusiform face area These results indicate that level of social anxiety mediates the neural response to emotional face perception in ASD (C) 2010 Elsevier Ltd All rights reserved
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