期刊
NEUROPSYCHOLOGIA
卷 46, 期 1, 页码 269-280出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2007.07.018
关键词
language; inferences; fMRI; functional connectivity; corpus callosum; cortical networks
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [U19HD035469, P50HD055748, P01HD035469] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH029617] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [K23DC006691] Funding Source: NIH RePORTER
- NICHD NIH HHS [U19 HD035469-06, U19 HD035469, U19 HD035469-10, U19 HD035469-060004, P01 HD035469, U19 HD035469-09, P50 HD055748, HD35469, U19 HD035469-08, U19 HD035469-07] Funding Source: Medline
- NIDCD NIH HHS [K23 DC006691-04, K23 DC006691, K23 DC006691-06] Funding Source: Medline
- NIMH NIH HHS [R01 MH029617-24, MH029617, R01 MH029617] Funding Source: Medline
The intersection of Theory of Mind (ToM) processing and complex narrative comprehension in high functioning autism was examined by comparing cortical activation during the reading of passages that required inferences based on either intentions, emotional states, or physical causality. Right hemisphere activation was substantially greater for all sentences in the autism group than in a matched control group suggesting decreased LH capacity in autism resulting in a spillover of processing to RH homologs. Moreover, the ToM network was disrupted. The autism group showed similar activation for all inference types in the right temporo-parietal component of the ToM network whereas the control participants selectively activated this network only when appropriate. The autism group had lower functional connectivity within the ToM network and also between the ToM and a left hemisphere language network. Furthermore, the within-network functional connectivity in autism was correlated with the size of the anterior portion of the corpus callosum. (c) 2007 Elsevier Ltd. All rights reserved.
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