期刊
NEUROPSYCHOLOGIA
卷 46, 期 10, 页码 2597-2601出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2008.04.007
关键词
leukoaraiosis; executive functioning; working memory; MRI white matter alterations; executive control; mental manipulation
资金
- NINDS NIH HHS [K23 NS060660, R01 NS082386] Funding Source: Medline
MRI leukoaraiosis (LA) is less likely to interfere with simple compared to more complex working memory (WM) skills. We hypothesize that LA within the left hemisphere negatively impacts higher-level WM processes in dementia. Participants with dementia (n = 64; MMSE = 22.0 +/- 3.4) performed a Backward Digit Task measuring simple storage/rehearsal (ANY-ORDER) and complex disengagement/temporal re-ordering (SERIAL-ORDER) recall. A visual rating scale categorized MRI-LA in five regions per hemisphere: frontal and parietal centrum semiovale, white matter around the frontal horns, body of the lateral ventricles and posterior horns. Amidst equivalent hemispheric LA scores [t(62) = -1.12, p > 0.05], correlations revealed an association between left-sided LA and SERIAL-ORDER recall (r = -0.31, p = 0.007) with LA around the posterior horn (rho = -0.30, p = 0.008) and frontal centrum semiovale (rho = -0.29, p = 0.01) showing the greatest association. Regression modeling confirmed the left posterior horn contribution to SERIAL-ORDER performance variance. Results suggest involvement of anterior (fronto-striatal) and more posterior (inferior parietal) white matter tracts in higher order WM deficits in dementia. (C) 2008 Elsevier Ltd. All rights reserved.
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