期刊
NEUROPSYCHOLOGIA
卷 46, 期 6, 页码 1667-1678出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2007.11.035
关键词
aging; Alzheimer disease; hippocampus; functional imaging; self; APOE genotype
资金
- NIA NIH HHS [R01 AG021155, R01 AG021155-01A2, R01 AG021155-04, R01 AG021155-03, R01 AG021155-02] Funding Source: Medline
- NIMH NIH HHS [R01 MH065723, R01 MH065723-03, R01 MH065723-06, R01 MH065723-02, R01 MH65723, R01 MH065723-05, R01 MH065723-04] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065723] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021155] Funding Source: NIH RePORTER
In the present study, we used fMRI to examine the influence of age on two other known risk factors for Alzheimer's disease (AD), APOE genotype and parental history of AD (FH status), during episodic encoding (ENC) and metacognitive self-appraisal (SA) paradigms. These paradigms have previously been shown to evoke activity from brain regions that are implicated in AD. First we examined the effect of age across the adult lifespan (age 18-84 years) on cerebral activity in a large sample (n = 23 1) of cognitively healthy individuals. Next we examined a subset (n = 155) on whom APOE status and FH status were known. For ENC, we found that increasing age was associated with reduced activity in the ventral temporal lobes and hippocampus. Our analysis of risk factors suggested that FH and age exerted independent effects, but APOE interacted with age such that APOE e4 carriers exhibit age-related increases in activity in the hippocampus. For the metacognifive SA task, increasing age was found to be associated with reduced activity in the medial prefrontal cortex, and increased activity in the mesial temporal lobe, posterior orbital cortex and striatum. Neither AD risk factor significantly modified age-related changes in brain activity during SA. These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given. (c) 2007 Elsevier Ltd. All rights reserved.
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