期刊
NEUROPHYSIOLOGY
卷 44, 期 3, 页码 255-264出版社
SPRINGER
DOI: 10.1007/s11062-012-9295-8
关键词
G protein-coupled receptors; 7-TMRs; scaffold proteins; protein-to-protein interactions
Receptors of the 7-TMR group (G protein-coupled receptors, GPCRs) are uniquely important from the fundamental physiological aspect because they mediate the effects of a majority of the known neuromediators and hormones. According to a widely accepted paradigm, activation of heterotrimetric G proteins is the initial step in the process of transduction of signals from these receptors to effectors. In recent times, increasing proof of the existence of G protein-independent mechanisms providing initiation of biochemical signals by these receptors and modulation of the excitability of the neurons has been accumulated. According to these data, 7-TMRs are able to interact with a few cytoplasmic scaffold proteins and take part in various protein-to-protein interactions. Despite the fact that functional importance of many such interactions remains unknown at present, the respective results indicate that the above processes are capable not only of providing G protein-independent transmission of signals from the 7-TMRs, but also of influencing pharmacological characteristics, cellular localization, and compartmentalization of the mentioned receptors.
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