期刊
NEUROPHARMACOLOGY
卷 76, 期 -, 页码 450-459出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2013.05.040
关键词
Pavlovian conditioning; Incentive salience; Sign-tracking; Goal-tracking; Conditioned motivation; Conditioned approach; Cocaine; Addiction
资金
- National Institute on Drug Abuse [R37 DA04294, P01 DA031656, F31 DA030799, F31 DA030801, T31 DA007281]
- NATIONAL INSTITUTE ON DRUG ABUSE [P01DA031656, T32DA007281, R37DA004294, F31DA030801, F31DA030799] Funding Source: NIH RePORTER
Cues associated with rewards, such as food or drugs of abuse, can themselves acquire motivational properties. Acting as incentive stimuli, such cues can exert powerful control over motivated behavior, and in the case of cues associated with drugs, they can goad continued drug-seeking behavior and relapse. However, recent studies reviewed here suggest that there are large individual differences in the extent to which food and drug cues are attributed with incentive salience. Rats prone to approach reward cues (sign-trackers) attribute greater motivational value to discrete localizable cues and interoceptive cues than do rats less prone to approach reward cues (goal-trackers). In contrast, contextual cues appear to exert greater control over motivated behavior in goal-trackers than sign-trackers. It is possible to predict, therefore, before any experience with drugs, in which animals specific classes of drug cues will most likely reinstate drug-seeking behavior. The finding that different individuals may be sensitive to different triggers capable of motivating behavior and producing relapse suggests there may be different pathways to addiction, and has implications for thinking about individualized treatment. (C) 2013 Elsevier Ltd. All rights reserved.
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