期刊
NEUROPHARMACOLOGY
卷 69, 期 -, 页码 75-81出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2012.03.005
关键词
Ion channels; HCN channels; KV7 channels; M-current; Epilepsy
资金
- European Research Council [ERC_2010_StG_20091118]
- MRC [G0700369]
- Wellcome Trust [WT087363MA]
- Medical Research Council [G0700369] Funding Source: researchfish
- MRC [G0700369] Funding Source: UKRI
Voltage-gated ion channels are important determinants of cellular excitability. The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) and K(V)7 (M-) channels are voltage-gated ion channels. Both channels are activated at sub-threshold potentials and have biophysical properties that mirror each other. K(V)7 channels inhibit neuronal excitability. Thus, mutations in K(V)7 channels that are associated with Benign Familial Neonatal Convulsions (BFNC) are likely to be epileptogenic. Mutations in HCN channels have also been associated with idiopathic epilepsies such as GEFS+. In addition, HCN channel expression and function are modulated during symptomatic epilepsies such as temporal lobe epilepsy. It is, though, unclear as to whether the changes in HCN channel expression and function associated with the various forms of epilepsy promote epileptogenesis or are adaptive. In this review, we discuss this as well as the potential for K(V)7 and HCN channels as drug targets for the treatment of epilepsy. This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据