期刊
NEUROPHARMACOLOGY
卷 64, 期 -, 页码 515-528出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2012.06.029
关键词
Cognitive enhancers; Animal models; Environmental enrichment; Physical exercise; Gene-environment interactions; Enviromimetics; Cognitive deficits; Neurodegeneration; Dementia; Alzheimer's disease; Huntington's disease; Parkinson's disease; Schizophrenia; Neurodevelopmental disorders; Neurological diseases; Psychiatric disorders
资金
- ARC Future Fellowship (FT3)
- NHMRC
This review will provide an overview of the non-drug based approaches that have been demonstrated to enhance cognitive function of the compromised brain, primarily focussed on the two most widely adopted paradigms of environmental enrichment and enhanced physical exercise. Environmental enrichment involves the generation of novelty and complexity in animal housing conditions which facilitates enhanced sensory and cognitive stimulation as well as physical activity. In a wide variety of animal models of brain disorders, environmental enrichment and exercise have been found to have beneficial effects, including cognitive enhancement, delayed disease onset, enhanced cellular plasticity and associated molecular processes. Potential cellular and molecular mechanisms will also be discussed, which have relevance for the future development of 'enviromimetics', drugs which could mimic or enhance the beneficial effects of environmental stimulation. This article is part of a Special Issue entitled 'Cognitive Enhancers'. (C) 2012 Elsevier Ltd. All rights reserved.
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