期刊
NEUROPHARMACOLOGY
卷 63, 期 4, 页码 635-641出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2012.05.014
关键词
Addiction; Treatment; Relapse; Neuroadaptation; Stress; Withdrawal
资金
- Centre National pour la Recherche Scientifique
- University of Poitiers
- Mission Interministerielle de la Lutte contre les Drogues et la Toxicomanie
- Region Poitou Charentes
- CPER 5 (Contrat de Projet Etat-Region)
- Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services
- French Ministry of Research
Recent studies have demonstrated that exposure to environmental enrichment (EE) during withdrawal periods reduces the risks of relapse to drug-seeking behavior. In this study, we investigated whether EE could prevent the development of time-dependent increases in cocaine-seeking behavior (incubation of craving). In addition, we investigated whether EE could eliminate already developed incubation and whether the effects of EE would last when enrichment is discontinued. For this, we allowed rats to self-administer cocaine for 10 daily 6 h sessions and measured cocaine-seeking 1,30 and 60 days after the last self-administration session. In between these tests, rats were kept in forced abstinence and housed either in EE or standard environments (SE). Between day 30 and 60 of withdrawal, half of the rats in each group were maintained in their original environmental condition and the other half was switched to the other environmental condition. We found that exposure to EE prevents development of incubation of cocaine craving and eliminates already developed incubation. In addition, contrary to our expectations, when EE was discontinued, its positive effects on incubation of craving disappeared. These results indicate that EE can reduce cocaine seeking but only temporarily and questions the hypothesis that EE can permanently eliminate the neural consequences of exposure to drugs of abuse. Therefore, stimulating environments could have positive effects on the treatment of cocaine addiction only if they are maintained for long periods of abstinence that encompass the time-frame during which addicts are most vulnerable to relapse. (C) 2012 Elsevier Ltd. All rights reserved.
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