期刊
NEUROPHARMACOLOGY
卷 62, 期 2, 页码 552-564出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2011.07.007
关键词
Maternal separation or isolation; Shock or trauma; Social defeat or resident-intruder; Ethanol or alcohol; Cocaine or amphetamine or psychostimulant; Opiate; Post-traumatic stress disorder; Alcoholism
资金
- National Institutes of Health from National Institute of Diabetes and Digestive and Kidney Diseases [DK26741]
- National Institute on Alcohol Abuse and Alcoholism [AA06420, AA08459, AA018914]
- National Institute on Drug Abuse [DA04043, DA04398, DA023957]
- Pearson Center for Alcoholism and Addiction Research
Drug abuse and dependence present significant health burdens for our society, affecting roughly 10% of the population. Stress likely contributes to the development and persistence of drug use; for example, rates of substance dependence are elevated among individuals diagnosed with post-traumatic stress disorder (PTSD). Thus, understanding the interaction between stress and drug use, and associated neuroadaptations, is key for developing therapies to combat substance use disorders. For this purpose, many rodent models of the effects of stress exposure on substance use have been developed; the models can be classified according to three categories of stress exposure: developmental, adult nonsocial, and adult social. The present review addresses preclinical findings on the effect of each type of trauma on responses to and self-administration of drugs of abuse by focusing on a key exemplar for each category. In addition, the potential efficacy of targeting neuropeptide systems that have been implicated in stress responses and stress system neuroadaptation in order to treat comorbid PTSD and substance abuse will be discussed. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据