期刊
NEUROPHARMACOLOGY
卷 62, 期 1, 页码 54-62出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2011.07.026
关键词
GABA(A) receptor; Anxiety; Depression; Benzodiazepines; Development
资金
- National Institutes of Health [R01MH080006, R03MH085149]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH085149, R01MH080006] Funding Source: NIH RePORTER
GABA(A) receptors mediate fast synaptic inhibitory neurotransmission throughout the central nervous system. Recent work indicates a role for GABA(A) receptors in physiologically modulating anxiety and depression levels. In this review, we summarize research that led to the identification of the essential role of GABA(A) receptors in counteracting trait anxiety and depression-related behaviors, and research aimed at identifying individual GABA(A) receptor subtypes involved in physiological and pharmacological modulation of emotions. This article is part of a Special Issue entitled 'Anxiety and Depression'. (C) 2011 Elsevier Ltd. All rights reserved.
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