期刊
NEUROPHARMACOLOGY
卷 63, 期 5, 页码 898-904出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2012.06.045
关键词
Repetitive transcranial magnetic stimulation; Monoamines; Dopamine; Serotonin; NMDA receptor; Microdialysis; Freely moving rats
资金
- German Federal Ministry of Education and Research (BMBF)
- Graduate School for Computing in Medicine and Life Sciences
- Germany's Excellence Initiative [DFG GSC 235/1]
Evidence exists that modulation of neuronal activity in nucleus accumbens shell region may re-establish normal function in various neuropsychiatric conditions such as drug-withdrawal, obsessive compulsive disorder, depression and chronic pain. Here, we study the effects of acute repetitive transcranial magnetic stimulation on monoamine outflow in the nucleus accumbens shell in awake and freely moving rats using in vivo microdialysis. To scale the biochemical results to the induced electric field in the rat brain, we obtained a realistic simulation of the stimulation scenario using a finite element model. Applying 20 Hz repetitive transcranial magnetic stimulation in 6 trains of 50 stimuli with 280 is pulse width at a magnetic field strength of 130% of the individual motor threshold, dopamine as well as serotonin outflow in the nucleus accumbens shell significantly increased compared to sham stimulation. Since the electric field decays rapidly with depth in the rat brain, we can conclude that the modulation in neurotransmitter outflow from the nucleus accumbens shell is presumably a remote effect of cortical stimulation. (C) 2012 Elsevier Ltd. All rights reserved.
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