期刊
NEUROPHARMACOLOGY
卷 56, 期 1, 页码 2-5出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2008.06.063
关键词
Ligand-gated ion channels; Nomenclature
资金
- Medical Research Council [G0601813] Funding Source: Medline
- NIAAA NIH HHS [R01 AA007680, R01 AA007680-17A1] Funding Source: Medline
- NIGMS NIH HHS [P01 GM058448, P01 GM058448-040004] Funding Source: Medline
- NINDS NIH HHS [P01 NS035985, P01 NS035985-080001] Funding Source: Medline
- MRC [G0601813] Funding Source: UKRI
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM058448] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS035985] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA007680] Funding Source: NIH RePORTER
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.
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