期刊
NEUROPHARMACOLOGY
卷 55, 期 6, 页码 922-931出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2008.05.013
关键词
Serotonin; 5-HT4 receptor; Memory; Feeding; Mood; Depression
Twenty years ago, we started the characterization of a 5-HT receptor Coupled to cAMP production in neurons. This receptor obviously had a different pharmacology to the other 5-HT receptors described at that time, i.e. the 5-HT1, 5-HT2, 5-HT3 receptors. We proposed to name it the 5-HT4 receptor. Nowadays, 5-HT4 receptors are one of the most studied GPCRs belonging to the rhodopsin family. Thanks to the existence of a great variety of ligands with inverse agonist, partial agonist, agonist and antagonist profiles, the pharmacological and physiological properties of this receptor are beginning to emerge. Although some 5-HT4 partial agonists have been on the market for gastro-intestinal pathologies, 5-HT4 receptor drugs have still to be commercialized for brain disorders. However, since 5-HT4 receptors have recognized effects on memory, depression and feeding in animal models, there is still hope for a therapeutic destiny of this interesting target in brain disorders. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据