期刊
NEUROPEPTIDES
卷 47, 期 6, 页码 489-495出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.npep.2013.10.011
关键词
Activity-dependent neuroprotective protein (ADNP); Axonal transport; Davunetide; NAP; Neurodegenerative diseases; Neurological disorders
资金
- Tel Aviv University
- AMN Foundation
- CFTAU Montreal Circle of Friends
- Barbara and Don Seal
- Oberfeld and the Adams families
- Adams Super Center for Brain Studies and at Tel Aviv University
- Dr. Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology
This review focuses on the therapeutic effects and mechanisms of action of NAP (davunetide), an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP) which was discovered in our laboratory. We have recently described the effects of NAP in neurodegenerative disorders, and we now review the beneficial effects of NAP and other microtubule-stabilizing agents on impairments in axonal transport. Experiments in animal models of microtubule-deficiency including tauopathy (spanning from drosophila to mammals) showed protection of axonal transport by microtubule-stabilizers and NAP, which was coupled to motor and cognitive protection. Clinical trials with NAP (davunetide) are reviewed paving the path to future developments. (C) 2013 Elsevier Ltd. All rights reserved.
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