期刊
NEUROPEPTIDES
卷 46, 期 6, 页码 285-289出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.npep.2012.09.007
关键词
Neuropeptide; Immunohistochemistry; Neuronal interaction
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24590241]
- Strategic Research Foundation from the Ministry of Education, Culture, Sports, Science and Technology of Japan [S0801015]
- Grants-in-Aid for Scientific Research [22591207, 24590241, 23500863] Funding Source: KAKEN
Neuropeptide Y (NPY) is a 36-amino-acid neuropeptide that was first discovered in porcine brain extracts and later in the porcine intestine. It is widely distributed in both the central and peripheral nervous systems and exerts a powerful orexigenic effect. NPY-producing neuronal cell bodies are abundantly localized in the medial arcuate nucleus of the hypothalamus, this being a brain center that integrates signals ,for energy homeostasis. Accumulated evidence shows that hypothalamic neuropeptides such as ghrelin, orexin, melanin-concentrating hormone (MCH), galanin-like peptide (GALP) and proopiomelanocortin (POMC) are involved in the regulation of feeding behavior and energy homeostasis via neuronal circuits in the hypothalamus. NPY also forms part of the feeding-regulating neuronal circuitry in conjunction with other feeding-regulating peptide-containing neurons within the hypothalamus. We summarize here current knowledge of the neuronal interactions between NPY and the different types of feeding-regulating peptide-containing neurons in the hypothalamus based on evidence at the immunohistochemical level and with calcium imaging techniques. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据