相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Kinase signaling pathways as potential targets in the treatment of Parkinson's disease
Eliso Greggio et al.
EXPERT REVIEW OF PROTEOMICS (2007)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau et al.
NATURE CELL BIOLOGY (2007)
Impact of recent genetic findings in Parkinson's disease
Christine Klein et al.
CURRENT OPINION IN NEUROLOGY (2007)
Deciphering the role of heterozygous mutations in genes associated with parkinsonism
Christine Klein et al.
LANCET NEUROLOGY (2007)
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain
Shinji Higashi et al.
BRAIN RESEARCH (2007)
PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains
Tetsuro Murakami et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
A. Di Fonzo et al.
NEUROLOGY (2007)
Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations
Susanne Steinlechner et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
J. Fuchs et al.
NEUROLOGY (2007)
Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model
Walter Maetzler et al.
NEUROBIOLOGY OF DISEASE (2007)
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 193M mutant
Rieko Setsuie et al.
NEUROCHEMISTRY INTERNATIONAL (2007)
Mutations in DJ-1 are rare in familial Parkinson disease
Nathan Pankratz et al.
NEUROSCIENCE LETTERS (2006)
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease
Linda Vercammen et al.
MOLECULAR THERAPY (2006)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
Chou Hung Sim et al.
HUMAN MOLECULAR GENETICS (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
A heterozygous effect for PINK1 mutations in Parkinson's disease?
Patrick M. Abou-Sleiman et al.
ANNALS OF NEUROLOGY (2006)
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
Danling Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations
Lianna Ishihara et al.
ARCHIVES OF NEUROLOGY (2006)
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
Demetrius M. Maraganore et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease
Masaaki Waragai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Miratul M. K. Muqit et al.
JOURNAL OF NEUROCHEMISTRY (2006)
PINK1 protein in normal human brain and Parkinson's disease
S. Gandhi et al.
BRAIN (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model
Ronald L. Klein et al.
NEUROSCIENCE LETTERS (2006)
PINK1 mutations in sporadic early-onset Parkinson's disease
Eng-King Tan et al.
MOVEMENT DISORDERS (2006)
Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease : Role of a single hit?
Katja Hedrich et al.
ARCHIVES OF NEUROLOGY (2006)
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline
MJ Casarejos et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human α-synuclein (1-120):: Implications for Lewy body disorders
GK Tofaris et al.
JOURNAL OF NEUROSCIENCE (2006)
LRRK2 mutations are a common cause of Parkinson's disease in Spain
IF Mata et al.
EUROPEAN JOURNAL OF NEUROLOGY (2006)
Parkinson's disease and LRRK2:: Frequency of a common mutation in US movement disorder clinics
DM Kay et al.
MOVEMENT DISORDERS (2006)
LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
ANNALS OF NEUROLOGY (2006)
Parkin enhances mitochondrial biogenesis in proliferating cells
Y Kuroda et al.
HUMAN MOLECULAR GENETICS (2006)
Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease
K Nishioka et al.
ANNALS OF NEUROLOGY (2006)
LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
S Lesage et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
LJ Ozelius et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Anatomical localization of Leucine-rich repeat kinase 2 in mouse brain
H Melrose et al.
NEUROSCIENCE (2006)
No definitive evidence for a role for the environment in the etiology of Parkinson's disease
John Hardy
MOVEMENT DISORDERS (2006)
Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
J Park et al.
GENE (2005)
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
L Silvestri et al.
HUMAN MOLECULAR GENETICS (2005)
The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor -: art. no. e65
S Goldwurm et al.
JOURNAL OF MEDICAL GENETICS (2005)
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
A Petit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
PP Pramstaller et al.
ANNALS OF NEUROLOGY (2005)
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss et al.
HUMAN MOLECULAR GENETICS (2005)
Effects of α-synuclein immunization in a mouse model of Parkinson's disease
E Masliah et al.
NEURON (2005)
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
A Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease
JH Jin et al.
MOLECULAR BRAIN RESEARCH (2005)
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
JC Greene et al.
HUMAN MOLECULAR GENETICS (2005)
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
MS Goldberg et al.
NEURON (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
UCHL1 is a Parkinson's disease susceptibility gene
DM Maraganore et al.
ANNALS OF NEUROLOGY (2004)
DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function
PJ Lockhart et al.
JOURNAL OF MEDICAL GENETICS (2004)
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
JA Olzmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
DJ-1 has a role in antioxidative stress to prevent cell death
T Taira et al.
EMBO REPORTS (2004)
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
R Bandopadhyay et al.
BRAIN (2004)
PINK1 mutations are associated with sporadic early-onset parkinsonism
EM Valente et al.
ANNALS OF NEUROLOGY (2004)
Genetic clues to the pathogenesis of Parkinson's disease
M Vila et al.
NATURE MEDICINE (2004)
How does parkin ligate ubiquitin to Parkinson's disease? First in molecular medicine review series
PJ Kahle et al.
EMBO REPORTS (2004)
PET neuroimaging and mutations in the DJ-1 gene
MCJ Dekker et al.
JOURNAL OF NEURAL TRANSMISSION (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations
LN Clark et al.
MOVEMENT DISORDERS (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Pathological properties of the Parkinson's disease-associated protein DJ-1 in α-synucleinopathies and tauopathies:: relevance for multiple system atrophy and Pick's disease
M Neumann et al.
ACTA NEUROPATHOLOGICA (2004)
Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein
W Choi et al.
FEBS LETTERS (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
R Hering et al.
HUMAN MUTATION (2004)
Parkinson disease with old-age onset
KA Jellinger
ARCHIVES OF NEUROLOGY (2003)
BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential
A Nakajima et al.
CANCER LETTERS (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
DW Miller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The role of pathogenic DJ-1 mutations in Parkinson's disease
PM Abou-Sleiman et al.
ANNALS OF NEUROLOGY (2003)
How much phenotypic variation can be attributed to parkin genotype?
E Lohmann et al.
ANNALS OF NEUROLOGY (2003)
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
FP Marx et al.
HUMAN MOLECULAR GENETICS (2003)
Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
SA Oliveira et al.
ANNALS OF NEUROLOGY (2003)
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease
T Foroud et al.
NEUROLOGY (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
F Darios et al.
HUMAN MOLECULAR GENETICS (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
The identification of Pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum
JC Abysalh et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization
DJ Moore et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism:: An 18F-dopa PET study
NL Khan et al.
ANNALS OF NEUROLOGY (2002)
The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
YC Liu et al.
CELL (2002)
Effects of coenzyme Q10 in early Parkinson disease -: Evidence of slowing of the functional decline
CW Shults et al.
ARCHIVES OF NEUROLOGY (2002)
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain.: Part II:: dihydropyrimidinase-related protein 2, α-enolase and heat shock cognate 71
A Castegna et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Concurrence of α-synuclein and tau brain pathology in the Contursi kindred
JE Duda et al.
ACTA NEUROPATHOLOGICA (2002)
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies
MG Schlossmacher et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Parkinson's disease:: one biochemical pathway to fit all genes?
R Krüger et al.
TRENDS IN MOLECULAR MEDICINE (2002)
Vesicle permeabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
MJ Volles et al.
BIOCHEMISTRY (2002)
PARK6-linked parkinsonism occurs in several European families
EM Valente et al.
ANNALS OF NEUROLOGY (2002)
A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1
M Funayama et al.
ANNALS OF NEUROLOGY (2002)
Lewy bodies and parkinsonism in families with parkin mutations
M Farrer et al.
ANNALS OF NEUROLOGY (2001)
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
M Unoki et al.
ONCOGENE (2001)
Familial parkinsonism with synuclein pathology -: Clinical and PET studies of A30P mutation carriers
R Krüger et al.
NEUROLOGY (2001)
Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
Y Tanaka et al.
HUMAN MOLECULAR GENETICS (2001)
Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36
EM Valente et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene
R Hilker et al.
ANNALS OF NEUROLOGY (2001)
Synucleinopathies - Clinical and pathological implications
JE Galvin et al.
ARCHIVES OF NEUROLOGY (2001)
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin
A Mitsumoto et al.
FREE RADICAL RESEARCH (2001)
Pure autonomic failure in association with human α-synucleinopathy
K Arai et al.
NEUROSCIENCE LETTERS (2000)
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
Y Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
Y Imai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
BI Giasson et al.
SCIENCE (2000)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura et al.
NATURE GENETICS (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
LC Serpell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Membrane association and protein conformation of α-synuclein in intact neurons -: Effect of Parkinson's disease-linked mutations
PJ McLean et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A Drosophila model of Parkinson's disease
MB Feany et al.
NATURE (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)
分享论文
