期刊
NEUROPATHOLOGY
卷 30, 期 2, 页码 189-193出版社
WILEY
DOI: 10.1111/j.1440-1789.2009.01088.x
关键词
ALS; amyotrophic lateral sclerosis; Golgi apparatus; pathology; review
资金
- Ministry of Health, Labour and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Protein synthesis and degradation systems in neurons are among the major subjects of study in neurobiology. These systems are believed to be the main pathways involved in ALS; however, the essential pathomechanisms that underlie this disease remain obscure. In addition to the ubiquitin-proteasomal and autophagic systems, several cytoplasmic organelles are also involved in ALS. Here, we present our data and discuss the main morphological abnormalities detected in the anterior horn cells of ALS patients.
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