期刊
NEURON
卷 99, 期 5, 页码 869-871出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.08.026
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资金
- NIA NIH HHS [F30 AG063468] Funding Source: Medline
- NIGMS NIH HHS [R01 GM045443] Funding Source: Medline
Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer's disease. Eftekharzadeh et al. (2018) demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases.
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