期刊
NEURON
卷 82, 期 2, 页码 380-397出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.02.040
关键词
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资金
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [1R01NS083801, F31NS086409]
- NIH [UL1 TR000153, AG00538]
- Whitehall foundation
- American Federation of Aging Research
- Alzheimer's Association
The colony-stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells. Genetic loss of the CSF1R blocks the normal population of resident microglia in the brain that originates from the yolk sac during early development. However, the role of CSF1R signaling in microglial homeostasis in the adult brain is largely unknown. To this end, we tested the effects of selective CSF1R inhibitors on microglia in adult mice. Surprisingly, extensive treatment results in elimination of similar to 99% of all microglia brain-wide, showing that microglia in the adult brain are physiologically dependent upon CSF1R signaling. Mice depleted of microglia show no behavioral or cognitive abnormalities, revealing that microglia are not necessary for these tasks. Finally, we discovered that the microglia-depleted brain completely repopulates with new microglia within 1 week of inhibitor cessation. Microglial repopulation throughout the CNS occurs through proliferation of nestin-positive cells that then differentiate into microglia.
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