期刊
NEURON
卷 84, 期 4, 页码 697-707出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.10.011
关键词
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资金
- Swedish Research Council [2013-3105, 2010-5421, 2009-6050]
- AstraZeneca RD, UK
- Agence Nationale de la Recherche [ANR-12-BSV4-0001-01]
- Michael J. Fox Foundation
Current neuroimaging techniques have very limited abilities to directly identify and quantify neurotransmitters from brain sections. We have developed a molecular-specific approach for the simultaneous imaging and quantitation of multiple neurotransmitters, precursors, and metabolites, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methoxytyramine, serotonin, GABA, glutamate, acetylcholine, and L-alpha-glycerylphosphorylcholine, in histological tissue sections at high spatial resolutions. The method is employed to directly measure changes in the absolute and relative levels of neurotransmitters in specific brain structures in animal disease models and in response to drug treatments, demonstrating the power of mass spectrometry imaging in neuroscience.
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