期刊
NEURON
卷 81, 期 4, 页码 847-859出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.01.001
关键词
-
资金
- National Institute on Deafness and Other Communication Disorders
- National Human Genome Research Institute [T32 HG00047]
- National Science Foundation
Olfactory sensory neurons express just one out of a possible similar to 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here, we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor activity. Moreover, we show that signaling through G protein beta gamma subunits is both necessary and sufficient to suppress the expression of odorant receptor genes and likely acts through histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive heterochromatin. These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron.
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