期刊
NEURON
卷 84, 期 5, 页码 1049-1064出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.10.051
关键词
-
资金
- NIH [RR19895, RR029676-01, P30 EY000785, T32 NS007224, R01 EY015788, R01 EY023105, R01 EY017353, T32 EY022313]
- Research to Prevent Blindness (RPB), Inc.
The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In sensory systems, patterned spontaneous activity before the onset of sensation is thought to influence this process, but this conclusion remains controversial, largely due to the inherent difficulty recording neural activity in early development. Here, we describe genetic and pharmacological manipulations of spontaneous retinal activity, assayed in vivo, that demonstrate a causal link between retinal waves and visual circuit refinement. We also report a decoupling of downstream activity in retinorecipient regions of the developing brain after retinal wave disruption. Significantly, we show that the spatiotemporal characteristics of retinal waves affect the development of specific visual circuits. These results conclusively establish retinal waves as necessary and instructive for circuit refinement in the developing nervous system and reveal how neural circuits adjust to altered patterns of activity prior to experience.
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