期刊
NEURON
卷 82, 期 6, 页码 1263-1270出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.04.038
关键词
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资金
- NIAAA [AA022239]
- NIMH (Conte Center for Neuroscience) [MH084020]
- Brain Science Institute
- Science of Learning Institute at Johns Hopkins
- National Multiple Sclerosis Society
Astrocytes perform crucial supportive functions, including neurotransmitter clearance, ion buffering, and metabolite delivery. They can also influence blood flow and neuronal activity by releasing glio-transmitters in response to intracellular Ca2+ transients. However, little is known about how astrocytes are engaged during different behaviors in vivo. Here we demonstrate that norepinephrine primes astrocytes to detect changes in cortical network activity. We show in mice that locomotion triggers simultaneous activation of astrocyte networks in multiple brain regions. This global stimulation of astrocytes was inhibited by alpha-adrenoceptor antagonists and abolished by depletion of norepinephrine from the brain. Although astrocytes in visual cortex of awake mice were rarely engaged when neurons were activated by light stimulation alone, pairing norepinephrine release with light stimulation markedly enhanced astrocyte Ca2+ signaling. Our findings indicate that norepinephrine shifts the gain of astrocyte networks according to behavioral state, enabling astrocytes to respond to local changes in neuronal activity.
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