期刊
NEURON
卷 83, 期 5, 页码 1117-1130出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.07.034
关键词
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资金
- Neural Imaging Center as part of an NINDS P30 Core Center grant [NS072030]
- Mahoney postdoctoral fellowship
- Goldenson postdoctoral fellowship
- Lefler postdoctoral fellowship
- FAPESP [2011/22639-8, 11/50761-2]
- CNPQ grant [304351/2009-1]
- NIH/NIDA [K01DA029044]
- Harvard/MIT Joint Research Grants Program in Basic Neuroscience
- Genise Goldenson fund
- Freudenberger award
- NIH [R01NS064583]
- Sloan research fellowship
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/50761-2, 11/22639-8] Funding Source: FAPESP
Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals an important feature of neurovascular interactions.
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