期刊
NEURON
卷 81, 期 3, 页码 629-640出版社
CELL PRESS
DOI: 10.1016/j.neuron.2013.11.026
关键词
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资金
- KIST Institutional Program [2E24210]
- World Class Institute Program of the National Research Foundation of Korea
- National Research Council of Science & Technology (NST), Republic of Korea [2E24540] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
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