期刊
NEURON
卷 81, 期 2, 页码 428-437出版社
CELL PRESS
DOI: 10.1016/j.neuron.2013.11.006
关键词
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资金
- Swiss National Science Foundation
- National Competence Center in Research of the Swiss Confederation on the synaptic basis of mental disorders
- Schering Foundation
- EMBO Long-Term Fellowships and Marie-Curie Actions
- Aquitaine Regional Council
- European Commission [HEALTH-F2-2009-241498]
- Novartis Research Foundation
Memories are acquired and encoded within large-scale neuronal networks spanning different brain areas. The anatomical and functional specificity of such long-range interactions and their role in learning is poorly understood. The amygdala and the medial prefrontal cortex (mPFC) are interconnected brain structures involved in the extinction of conditioned fear. Here, we show that a defined subpopulation of basal amygdala (BA) projection neurons targeting the prelimbic (PL) subdivision of mPFC is active during states of high fear, whereas BA neurons targeting the infralimbic (IL) subdivision are recruited, and exhibit cell-type-specific plasticity, during fear extinction. Pathway-specific optogenetic manipulations demonstrate that the activity balance between pathways is causally involved in fear extinction. Together, our findings demonstrate that, although intermingled locally, long-range connectivity defines distinct subpopulations of amygdala projection neurons and indicate that the formation of long-term extinction memories depends on the balance of activity between two defined amygdala-prefrontal pathways.
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