期刊
NEURON
卷 83, 期 3, 页码 663-678出版社
CELL PRESS
DOI: 10.1016/j.neuron.2014.07.002
关键词
-
资金
- Swedish Brain Foundation (Hjarnfonden)
- Karolinska Institutet Strategic Research program in Neuroscience (StratNeuro)
- Magnus Bergvall Stiftelse
- Ake Wibergs Stiftelse
- StratNeuro
- ERC
- Swedish Research Council
- Williams K. Bowes Jr. Foundation
The serotonin system is proposed to regulate physiology and behavior and to underlie mood disorders; nevertheless, the circuitry controlling serotonergic neurons remains uncharacterized. We therefore generated a comprehensive whole-brain atlas defining the monosynaptic inputs onto forebrain-projecting serotonergic neurons of dorsal versus median raphe based on a genetically restricted transsynaptic retrograde tracing strategy. We identified discrete inputs onto serotonergic neurons from forebrain and brainstem neurons, with specific inputs from hypothalamus, cortex, basal ganglia, and midbrain, displaying a greater than anticipated complexity and diversity in cell-type-specific connectivity. We identified and functionally confirmed monosynaptic glutamatergic inputs from prefrontal cortex and lateral habenula onto serotonergic neurons as well as a direct GABAergic input from striatal projection neurons. In summary, our findings emphasize the role of hyperdirect inputs to serotonergic neurons. Cell-type-specific classification of connectivity patterns will allow for further functional analysis of the diverse but specific inputs that control serotonergic neurons during behavior.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据