期刊
NEURON
卷 80, 期 3, 页码 633-647出版社
CELL PRESS
DOI: 10.1016/j.neuron.2013.10.045
关键词
-
资金
- NIH [R01 DA023999, R01 NS014841]
- Kavli Institute for Neuroscience at Yale
- NIH/NIMH [R01 MH100027, R37 MH060233, P50 HD055784, R01 MH094714]
- Simons SFARI Award [206744]
To understand the emergence of human higher cognition, we must understand its biological substrate-the cerebral cortex, which considers itself the crowning achievement of evolution. Here, we describe how advances in developmental neurobiology, coupled with those in genetics, including adaptive protein evolution via gene duplications and the emergence of novel regulatory elements, can provide insights into the evolutionary mechanisms culminating in the human cerebrum. Given that the massive expansion of the cortical surface and elaboration of its connections in humans originates from developmental events, understanding the genetic regulation of cell number, neuronal migration to proper layers, columns, and regions, and ultimately their differentiation into specific phenotypes, is critical. The pre- and postnatal environment also interacts with the cellular substrate to yield a basic network that is refined via selection and elimination of synaptic connections, a process that is prolonged in humans. This knowledge provides essential insight into the pathogenesis of human-specific neuropsychiatric disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据