期刊
NEURON
卷 75, 期 4, 页码 585-592出版社
CELL PRESS
DOI: 10.1016/j.neuron.2012.06.034
关键词
-
资金
- NSF [IOS 0542372, DMR-0820492]
- HFSP [RGY0042-]
- NIH [P30 NS45713, F31 DC011467, R00 GM87533]
- DGIST MIREBrain and Convergence Science Center [12-BD-0403]
- Ministry of Education, Science and Technology, Korea [2012009385]
- Natural Sciences and Engineering Research Council of Canada [PGS-D3]
- Brandeis National Committee
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0842452] Funding Source: National Science Foundation
Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to social hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据