期刊
NEURON
卷 76, 期 3, 页码 518-525出版社
CELL PRESS
DOI: 10.1016/j.neuron.2012.08.041
关键词
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资金
- National Institutes of Health [RO1EY019498, RO1EY013528]
- Human Frontier Science Program
- National Postdoctoral Award Program for Advancing Women in Science
- Edmond and Lily Safra (ELSC) Fellowship
- NIH [000231-UNC, 030036-UCD]
Direction selectivity in the retina is mediated by direction-selective ganglion cells. These cells are part of a circuit in which they are asymmetrically wired to inhibitory neurons. Thus, they respond strongly to an image moving in the preferred direction and weakly to an image moving in the opposite (null) direction. Here, we demonstrate that adaptation with short visual stimulation of a direction-selective ganglion cell using drifting gratings can reverse this cell's directional preference by 180 degrees. This reversal is robust, long lasting, and independent of the animal's age. Our findings indicate that, even within circuits that are hardwired, the computation of direction can be altered by dynamic circuit mechanisms that are guided by visual stimulation.
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