期刊
NEURON
卷 76, 期 4, 页码 804-812出版社
CELL PRESS
DOI: 10.1016/j.neuron.2012.09.028
关键词
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资金
- National Institutes of Health [R01-MH058883, R01-MH081975]
- National Center for Research Resources [U54 RR026139]
- National Institute on Minority Health and Health Disparities [8U54MD 007587-03]
- Consejo Nacional de Ciencia y Tecnologia fellowship
- APA Diversity Program in Neuroscience fellowship
- COR program [T34-MH19134]
- [R36-H089296]
The prefrontal cortex (PFC) regulates emotional responses, but it is unclear how PFC integrates diverse inputs to select the appropriate response. We therefore evaluated the contribution of basolateral amygdala (BLA) and ventral hippocampus (vHPC) inputs to fear signaling in the prelimbic (PL) cortex, a PEG region critical for the expression of conditioned fear. In conditioned rats trained to press for food, BLA inactivation decreased the activity of projection cells in PL, and reduced PL conditioned tone responses. In contrast, vHPC inactivation decreased activity of interneurons in PL and increased PL conditioned tone responses. Consistent with hippocampal gating of fear after extinction, vHPC inactivation increased fear and PL pyramidal activity in extinguished, but not in conditioned, rats. These results suggest a prefrontal circuit whereby hippocampus gates amygdala-based fear. Thus, deficient hippocampal inhibition of PEG may underlie emotional disorders, especially in light of reduced hippocampal volume observed in depression and PTSD.
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