期刊
NEURON
卷 76, 期 1, 页码 82-97出版社
CELL PRESS
DOI: 10.1016/j.neuron.2012.08.035
关键词
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资金
- National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) [R01NS055035, R01NS058443, R21NS058330, R01NS021749]
- National Institute of General Medical Sciences (NIGMS), NIH [R01GM098931, R01GM085788]
- National Institute of Mental Health, NIH [R01MH067122]
Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, central pattern generation, and sensorimotor integration. Invertebrate model systems have enabled detailed experimental analysis using combined genetic, behavioral, and physiological approaches. Here we review selected examples of neuropeptide modulation in crustaceans, mollusks, insects, and nematodes, with a particular emphasis on the genetic model organisms Drosophila melanogaster and Caenorhabditis elegans, where remarkable progress has been made. On the basis of this survey, we provide several integrating conceptual principles for understanding how neuropeptides modulate circuit function, and also propose that continued progress in this area requires increased emphasis on the development of richer, more sophisticated behavioral paradigms.
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