期刊
NEURON
卷 75, 期 6, 页码 981-991出版社
CELL PRESS
DOI: 10.1016/j.neuron.2012.07.026
关键词
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资金
- Simons Foundation SFARI grant [177638]
- ISF grants
- Bikura grant
- Clore and Kahn postdoctoral fellowships
- Pennsylvania Department of Health SAP [4100047862]
- NICHD/NIDCD [PO1/U19]
- NIH/NICHD University of Pittsburgh Autism Center of Excellence [HD055748]
Autism has been described as a disorder of general neural processing, but the particular processing characteristics that might be abnormal in autism have mostly remained obscure. Here, we present evidence of one such characteristic: poor evoked response reliability. We compared cortical response amplitude and reliability (consistency across trials) in visual, auditory, and somatosensory cortices of high-functioning individuals with autism and controls. Mean response amplitudes were statistically indistinguishable across groups, yet trial-by-trial response reliability was significantly weaker in autism, yielding smaller signal-to-noise ratios in all sensory systems. Response reliability differences were evident only in evoked cortical responses and not in ongoing resting-state activity. These findings reveal that abnormally unreliable cortical responses, even to elementary nonsocial sensory stimuli, may represent a fundamental physiological alteration of neural processing in autism. The results motivate a critical expansion of autism research to determine whether (and how) basic neural processing properties such as reliability, plasticity, and adaptation/habituation are altered in autism.
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